PhD defence: Alexandra Amalie Uglebjerg Pedersen
Cardiovascular magnetic resonance can visualize coronary artery disease and assess aortic valve prosthesis performance
Info about event
Time
Location
Auditorium G206-145, Aarhus University Hospital
On Monday 12 January at 14:00, Alexandra Amalie Uglebjerg Pedersen defends her PhD dissertation entitled "Cardiovascular Magnetic Resonance Imaging for Coronary Atherosclerotic Plaque Visualization and Transcatheter Aortic Valve Performance Assessment".
A PhD project from Aarhus University, Health investigates the use of advanced cardiovascular magnetic resonance (CMR) imaging for the assessment of coronary atherosclerosis and prosthetic heart valve function.
CMR enables enables detailed evaluation of cardiac anatomy, function, and tissue characteristics without exposing patients to ionizing radiation. Recent technological advances in image acquisition and reconstruction techniques have expanded its utility to include coronary artery imaging as well as quantitative assessment of blood flow and heart valve function.
In this project, patients with coronary artery disease were examined using a novel CMR technique that allows for characterization of coronary plaques without the use of ionizing radiation or contrast agents. When compared with cardiac computed tomography (CT), only partial overlap in measured plaque burden was observed, indicating that the two modalities capture different biological components of atherosclerotic disease.
Furthermore, CMR was used to assess prosthetic heart valve performance in patients undergoing transcatheter aortic valve implantation (TAVI). In a randomized clinical trial, two transcatheter valve systems were compared. Using phase-contrast CMR, valve opening area and regurgitation were quantified and compared between devices. The findings demonstrate good overall performance of contemporary aortic valve prostheses with low rates of paravalvular regurgitation for both prostheses. The results highlight the value of CMR for detailed, quantitative evaluation of prosthetic valve function as a complement to echocardiography.
The summary is written by the PhD student.
The defence is public and takes place in auditorium G206-145, Aarhus University Hospital. Please see the press release for more information.
Contact
PhD student Alexandra Amalie Uglebjerg Pedersen
Mail: aup@clin.au.dk
Phone: +45 30704436