Aarhus University Seal / Aarhus Universitets segl

PhD defence: Camilla Darum Sørensen

Recovery of monocytes after allogeneic stem cell transplantation

Info about event

Time

Monday 30 May 2022,  at 10:15 - 12:15

Location

William Scharff Auditorium 1253- 317, Aarhus University, Bartholins Allé 3, Aarhus C

On Monday 30 May at 10:15, Camilla Darum Sørensen defends her PhD dissertation entitled "Immune reconstitution following allogeneic hematopoietic stem cell transplantation - with special focus on monocytes".

Allogeneic stem cell transplantation is a potentially curative treatment modality for patients with leukemia. It is of great importance that the immune cells recover sufficiently as they serve to eliminate residual cancer cells and to protect the patient against infections. At the same time, the newly established donor cells may attack the patient's own tissue by the so-called acute graft-versus-host disease (aGVHD). While the adaptiv immune system has been thoroughly investigated in this regard, the role of the innate immune cells are less studied.

A recent Ph.D. study from Aarhus University, Health, has investigated how monocytes regenerate after allogeneic stem cell transplantaion in 16 cancer patients from Aarhus University Hospital. By means of flow cytometry and DNA analyses, three monocyte subsets (i.e., classical, intermediate, and nonclassical monocytes) were longitudinally examined in the peripheral blood of the patients from the time of transplantation till day 90 post treatment.

The results show that the monocytes are quickly reestablished after transplantation and that patients developing aGVHD have an increased amount of classical and intermediate monocytes early after transplantation compared to patients without aGVHD.

The summary is written by the PhD student.

The defence is public and takes place in the William Scharff Auditorium 1253- 317, Aarhus University, Bartholins Allé 3, Aarhus C. Please read the attached press release for more information.

Contact

PhD student Camilla Darum Sørensen

Mail: cdarum@biomed.au.dk

Phone: (+45) 61719169

Read full press release