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PhD defence: Jeyanthini Risikesan

VLDL-Triglyceride and Free Fatty Acid kinetics in Metabolic Associated Fatty Liver Disease: Effects of exercise and hyperinsulinemia on heart and liver metabolism and splanchnic balances

Info about event

Time

Thursday 11 August 2022,  at 14:00 - 16:00

Location

Auditorium J116-113, Aarhus University Hospital, Entrance J, Level 1, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N

On Thursday 11 August at 14:00, Jeyanthini Risikesan defends her PhD dissertation entitled "VLDL-Triglyceride and Free Fatty Acid kinetics in Metabolic Associated Fatty Liver Disease: Effects of exercise and hyperinsulinemia on heart and liver metabolism and splanchnic balances".

Metabolically associated hepatic steatosis (MAFLD-) is associated with obesity and altered lipoprotein metabolism and risk of development of steatohepatitis (MAFLD+). Abnormal hepatic (splanchnic) lipid handling may promote liver fat accumulation and increase the risk of MAFLD+ and the development of CVD. Previous studies have reported that FFA originating from 1) adipose tissue lipolysis; 2) chylomicrons; 3) hepatic de novo lipogenesis; and 4) lipoprotein remnmants are likely involved in MAFLD development. Exercise and weight loss are the only treatment modalities for MAFLD. The aim of this PhD was to gain insight into the hepatic (splanchnic) and systemic lipid handling in obese subjects with MAFLD+ and MAFLD- and healthy subjects without MAFLD to identify VLDL-TG and FFA differences between these groups. Three studies of hepatic and systemic lipid handling during different interventions are included.

The summary is written by the PhD student.

The defence is public and takes place in Auditorium J116-113, Aarhus University Hospital, Entrance J, Level 1, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N. Please read the attached press release for more information.

Contact

PhD student Jeyanthini Risikesan

Mail: jeyanrk@clin.au.dk

Phone: (+45) 60649961

Read full press release