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PhD defence: Karen Marie Juul Sørensen

Sortilin in Excitatory and Inhibitory Neurons

Info about event

Time

Friday 12 April 2024,  at 13:00 - 15:00

Location

Lille Anatomisk Auditorium (Building 1231, room 424), Aarhus University

On Friday 12 April at 13.00, Karen Marie Juul Sørensen defends her PhD dissertation entitled "The VPS10P Domain Receptor Sortilin in Excitatory and Inhibitory Neurons".

The receptor protein sortilin is highly expressed in neurons where it regulates neuronal functions and synaptic plasticity; functions that are critically involved in learning and memory.

In this PhD project from Aarhus University, we have investigated the role of sortilin in different neuronal subpopulations and its implications in learning, memory, synaptic transmission, and network activity. To accomplished this, we generated transgenic mice with sortilin deletion in inhibitory or excitatory neurons, respectively.

We found that sortilin deletion in either excitatory or inhibitory neurons resulted in distinct behavioral traits. Using electrophysiology and calcium imaging, we demonstrated that sortilin deficiency alters synaptic function and neuronal network synchronization. Collectively, our findings demonstrate that sortilin contributes to neurotransmission by influencing the balance between excitation and inhibition.

The summary is written by the PhD student. 

The defence is public and takes place in Lille Anatomisk Auditorium (Building 1231, room 424), Aarhus University and online. Please see the press release for more information.

Contact

PhD student Karen Marie Juul Sørensen
Mail: kmjs@biomed.au.dk 
Phone: +45 21846211 

Read full press release