On Thursday 25 June at 13:00, Lara Marziani defends her PhD disseration entitled “Exploring the therapeutic potential of remote ischemic conditioning-induced miRNAs in stroke: mechanistic insight into modulating transcriptomic and functional changes in immortalized human brain microvascular endothelial cells under inflammatory conditions”.

Stroke remains one of the leading causes of death and long-term disability worldwide. Although current treatments focus primarily on restoring cerebral blood flow, many patients continue to experience secondary brain injury, including neuroinflammation, blood-brain barrier dysfunction and impaired vascular repair. These mechanisms can contribute to long-term functional and cognitive impairment, highlighting the need for new therapeutic strategies. 

Remote Ischemic Conditioning (RIC) is a non-invasive medical procedure aimed at offering neuroprotection beyond the limited time window of conventional stroke treatments. Its biological activity is thought to be mediated, at least in part, by circulating factors, including microRNAs, which may contribute to modulate angiogenesis, a key process involved in post-stroke repair. 

The summary is written by the PhD student.

The defence is public and takes place in the MOMA auditorium, Aarhus University. Please see the press release for more information. 

Contact

PhD student Lara Marziani
Mail: lara.marziani@cfin.au.dk 
Phone: +45 50365009

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