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PhD defence: Malene Blond Ipsen

Identification of genomic factors contributing to drug resistance in prostate cancer

Info about event


Friday 21 June 2024,  at 13:00 - 15:00


Auditorium, ground floor, Department of Molecular Medicine (MOMA), Aarhus University Hospital

On Friday 21 June at 13.00, Malene Blond Ipsen defends her PhD dissertation entitled "Investigating PARP Inhibitor Resistance Mechanisms in Prostate Cancer Through Genome-Wide CRISPR-Cas9 Screening".

Prostate cancer is the most diagnosed cancer among Danish men, with over 4500 new cases each year. Aggressive or metastatic forms of the disease are incurable. Hence, treatment is only life prolonging and often fails due to the inevitable development of treatment resistance. This necessitates frequent changes in treatment regimens, resulting in the use of ineffective drugs that cause economic burdens and increased risk of unnecessary side effects. 

Addressing these clinical challenges, this Ph.D. research focused on identifying genomic changes that contribute to drug resistance in prostate cancer, with emphasis on drugs given to patients with DNA repair gene mutations, namely PARP inhibitors. Utilizing CRISPR technology, thousands of genomic alterations were examined, leading to the identification of a panel of genes for further investigation. This research uncovered previously unrecognized genes and molecular changes associated with PARP inhibitor drug resistance, offering new insights into the management of prostate cancer.

The summary is written by the PhD student. 

The defence is public and takes place in the auditorium, ground floor, at Department of Molecular Medicine (MOMA), Aarhus University Hospital. Please see the press release for more information. 


PhD student Malene Blond Ipsen
Mail: maleneblond@clin.au.dk   
Phone: +45 30698434

Read full press release