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PhD defence: Pernille Jul Clemmensen

Maternal exposure to nitrate and nitrosatable drugs in pregnancy and reproductive health in sons and daughters

Info about event

Time

Friday 12 April 2024,  at 13:00 - 15:00

Location

Samfundsmedicinsk auditorium, building 1262, Aarhus University

On Friday 12 April at 13.00, Pernille Jul Clemmensen defends her PhD dissertation entitled "Prenatal exposure to nitrate and nitrosatable drugs and reproductive health".

The reproductive system develops during fetal life, and exposures during this sensitive period may affect reproductive health later in life. Nitrate is ingested from drinking water and diet, whereas nitrosatable drugs are commonly used drugs that can react with nitrate and form potentially teratogenic compounds. It has not yet been investigated whether exposure to nitrate or nitrosatable drugs during pregnancy affects the onset of puberty or semen quality. The studies in this PhD project are based on data from the "Danish National Birth Cohort", where data have been collected continuously from pregnancy through childhood and adolescence. As a result, the cohort contains details on maternal lifestyle, dietary habits, and drug use during pregnancy, as well as information on pubertal development of 15,819 sons and daughters, along with semen quality and hormone levels of 1,058 sons. This comprehensive dataset was used in the current PhD project together with information on nitrate levels in Danish drinking water obtained from the drinking water database "Jupiter". The findings from the PhD project contribute to the expanding body of literature on the potential health effects of nitrate and nitrosatable drug exposure during pregnancy.

The summary is written by the PhD student.

The defence is public and takes at Aarhus University in Samfundsmedicinsk auditorium. Please see the press release for more information.

Contact

PhD student Pernille Jul Clemmensen
Mail: p.jul@ph.au.dk 
Phone: +4561667974

Read full press release