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PhD defence: Simon Grund Sørensen

Mutation patterns may aid clinicians in selecting cancer treatments

Info about event


Monday 30 May 2022,  at 10:00 - 12:00


The auditorium (ground floor), Department of Molecular Medicine (MOMA), Brendstrupgårdsvej 21A, Aarhus

On Monday 30 May, Simon Grund Sørensen defends his PhD dissertation entitled "The genetic footprint of DNA damage response deficiencies in cancer".

DNA is constantly exposed to damage due to exposure to radiation and chemicals, as well as damages occuring during cellular processes. Most damages are repaired by a complex set of repair mechanisms. However, many human cancers are characterised by the loss of one or more DNA damage repair mechanisms. Correctly identifying the loss of a DNA repair may help doctors select the appropriate treatment for the individual tumour, and will aid in the understanding of cancer genetics. The loss of a DNA repair mechanism can be expected to cause an increased number of DNA mutations genome wide. Due to this, the loss of DNA repair may be predicted by summarising mutations across the whole DNA.

A new PhD project from Aarhus University, Health, has used machine learning to systematically characterise mutation patterns across more than 6,000 human cancers, with deficiencies across DNA damage response mechanisms. The mutation patterns are associated with the loss of specific DNA damage response mechanisms, which in turn may help predict how individual tumors respond to treatment.

The summary is written by the PhD student.

The defence is public and takes place in the auditorium (ground floor), MOMA - the Department of Molecular Medicine, Brendstrupgårdsvej 21A, Aarhus. Please read the attached press release for more information.


PhD student Simon Grund Sørensen
Mail: simong@clin.au.dk  
Phone: (+45)26533533

Read full press release