PhD defence: Hakim Ben Abdallah
The role of heat shock protein 90 in inflammatory skin diseases
Info about event
Time
Location
Auditorium G206-142, Aarhus University Hospital
On Tuesday 21 May at 14:30, Hakim Ben Abdallah defends his PhD dissertation entitled "The role of heat shock protein 90 in inflammatory skin diseases".
Heat shock protein 90 (HSP90) may be a novel drug target for treating inflammatory skin diseases. A recent PhD project from Aarhus University (Health) investigated the therapeutic potential of HSP90 inhibition in preclinical models of cutaneous inflammation and in a proof-of-concept clinical study.
Despite the advancements in immunomodulating drugs, novel therapeutics are warranted for inflammatory skin diseases. HSP90 is an abundantly expressed protein involved in the folding, and thereby promoting the activity, of hundreds of client proteins. Recent studies indicate that inhibition of HSP90 may alleviate skin inflammation in psoriasis and autoimmune bullous diseases, but the evidence is very limited.
In this PhD project, the feasibility of HSP90 inhibition as a novel therapeutic mode-of-action for inflammatory skin diseases was evaluated in preclinical models of cutaneous inflammation (i.e., irritant contact dermatitis and atopic dermatitis) and in a clinical study with hidradenitis suppurativa patients. The results from the PhD project advance our knowledge of the therapeutic potential of HSP90 inhibition in inflammatory skin diseases.
The summary is written by the PhD student.
The defence is public and takes place in Auditorium G206-142, Aarhus University Hospital. Please see the press release for more information.
Contact
PhD student Hakim Ben Abdallah
Mail: hba@clin.au.dk
Phone: (+45) 31146533