On Thursday 30 May at 14:00, Simone Buchardt Brandt defends her PhD dissertation entitled "Benign Ureteroentric Strictures After Radical Cystectomy and Ileal Conduit – Definition, Etiology, and Prevention".

Bladder cancer, a global concern, and often treated with removal of the bladder, a radical cystectomy with urinary diversion. In Denmark, most opt for an ileal conduit. This surgery poses risks, including ureteroenteric strictures (UES), especially on the left side, presumably due to surgical nuances. A new phd project from Aarhus University explores this and evaluates a new approach, the retrosigmoid ileal conduit.

This dissertation is based on four papers from three studies:
Paper I: Our retrospective study reveals that 15.7% of patients undergoing radical cystectomy with ileal conduit develop UES, shedding light on varied presentation and treatment approaches.
Paper II: Examining risk factors for UES after cystectomy, our study identifies side-specific associations, suggesting different etiologies for left and right-sided strictures.
Paper III: In the first randomized trial of its kind, we demonstrate the feasibility and safety of the retrosigmoid ileal conduit compared to conventional ileal conduit, potentially offering a solution to reduce the risk of left-sided UES.
Paper IV: Early results from our ongoing trial indicate a promising decrease in left-sided UES with the use of the retrosigmoid ileal conduit, highlighting its potential as a preventive measure in bladder cancer surgery.

The summary is written by the PhD student.

The defence is public and takes place in Auditorium C114-101, entrance C, Aarhus University Hospital. Please see the press release for more information. 

Contact

PhD student Simone Buchardt Brandt

Mail: simbra@clin.au.dk

Phone: (+45) 41624830

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