On Thursday 30 April at 13:00, Aisha Shigna Nadukkandy defends her PhD dissertation entitled “A systems-level understanding of endothelial dynamics in diabetes and aging”.

Endothelial cells (ECs) form the innermost lining of blood vessels and play a critical role in maintaining tissue homeostasis. Due to their ubiquitous nature, ECs are often the first responders to any external cues that disrupt normal physiological balance. As a result, endothelial dysfunction is a significant driver of disease progression in various conditions, including diabetes and aging-associated cardiovascular disease. However, ECs are highly heterogeneous and exhibit strong organ-specific characteristics. This complexity explains why the one-size-fits-all approach to treating endothelial dysfunction during diseases has often failed to yield the desired results. Thus, there is an increasing demand for studies that focus on how ECs adapt to stress in a tissue- and time-dependent manner. 

A new PhD study from Aarhus University addresses this challenge by providing a systems-level understanding of endothelial dynamics during metabolic disease and physiological aging. By integrating single-cell and spatial multi-omic approaches, this study offers new insights into how vascular systems respond to complex biological stress.

The summary is written by the PhD student.

The defence is public and takes place in auditorium 424, building 1231, Aarhus University. Please see the press release for more information. 

Contact

PhD student Aisha Shigna Nadukkandy
Mail: aishan@uni.au.dk 
Phone: +4531866435

Read full press release