On Wednesday 4 September at 14.00, Anne Karmisholt Grosen defends her PhD dissertation entitled "Optimising faeces donor screening and selection by establishing evidence-based donor criteria".

Faecal microbiota transplantation (FMT) involves the transfer of intestinal microbiota from a healthy donor to a patient. The choice of donor is crucial to ensure a safe and possible also effective treatment. Despite this, faeces donation criteria are not based on evidence.

The aim of this project was to produce knowledge that will contribute to establishing evidence-based criteria for faeces donation. A wide range of donor criteria are addressed, including gastrointestinal symptoms and bowel habits, asymptomatic Helicobacter pylori carriage, and an assessment of whether donor factors affect the clinical effect of FMT in patients with Clostridioides difficile infection. 

Using data on a healthy reference, we describe common gastrointestinal symptoms and common bowel habits in healthy adults. We found no evidence of H. pylori transmission from donors to recipients by FMT administered via oral capsules. The project provides new insights into associations between donor factors and the clinical effect of FMT that may optimise donor selection. Altogether, the project contributes important insights into aspects of FMT safety and efficacy that contribute to establishing evidence-based donor criteria.

The summary is written by the PhD student. 

The defence is public and takes place in auditorium B (Entrance G, Room G206-142), Aarhus University Hospital. Please see the press release for more information. 

Contact

PhD student Anne Karmisholt Grosen
Mail: annegros@rm.dk 
Phone: 28865825

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