On Friday 29 May at 11:00, Madison Clark defends her PhD dissertation entitled "Lipoxin Signaling in Cardiometabolic and Cardiac Disease: Roles in Adipose Inflammation, Vascular Remodeling, and Cardiac Dysfunction".

Chronic inflammation plays an important role in the development of obesity-related cardiometabolic disease and several forms of heart disease. While many current anti-inflammatory treatments can suppress the immune system, specialized pro-resolving mediators are naturally produced molecules that help the body actively resolve inflammation while maintaining normal immune defense.

In her PhD project at Aarhus University, Madison Clark investigated how two specialized pro-resolving mediators, Lipoxin A₄ and Lipoxin B₄, influence inflammatory responses and tissue remodeling in experimental models of obesity and cardiac disease. The project included studies of cardiac inflammation and dysfunction in dilated cardiomyopathy, transcriptomic changes in adipose tissue during obesity, and obesity-associated vascular remodeling in peripheral tissues.

The studies demonstrated that lipoxin signaling influences inflammatory and remodeling pathways in a sex-dependent manner across several disease models. The findings contribute to a growing understanding of how inflammation is actively resolved and highlight resolution-based therapies as a promising future strategy for limiting chronic inflammation without compromising normal immune function.

The summary is written by the PhD student.

The defence is public and takes place in Auditorium Verdensrummet (A201-170), Entrance A, Steno Diabetes Center Aar-hus, Aarhus University Hospital. Please see the press release for more information. 

Contact

PhD student Madison Clark
Mail: mclark@biomed.au.dk 
Phone: +4522635422

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