On Friday 11 April at 14:00, Mette Louise Gram Kjærulff defends her PhD dissertation entitled "Effects of Alternate Day Fasting on Cardiac Substrate Metabolism and Function".

Ketone metabolism plays a central role in energy homeostasis, providing an alternative substrate for tissues such as the brain and heart under conditions of limited carbohydrate availability. This PhD project explores key aspects of ketone metabolism, its assessment using advanced imaging techniques, and its modulation by dietary interventions, with a particular focus on myocardial function and metabolism. The PhD project comprises three studies that collectively provide new insights into ketone metabolism, establish PET imaging as a reliable tool for investigating myocardial ketone dynamics, and highlight the potential of dietary interventions like ADF to enhance cardiovascular function. The results contribute to a deeper understanding of the interplay between metabolism and cardiovascular health, offering pathways for therapeutic innovation in metabolic and cardiovascular diseases.

The summary is written by the PhD student.

The defence is public and takes place in Auditorium Verdensrummet (A201-170), Entrance A, Steno Diabetes Center Aarhus, Aarhus University Hospital. Please see the press release for more information. 

Contact

PhD student Mette Louise Gram Kjærulff
Mail: metkju@clin.au.dk 
Phone: 60155311

Read full press release