On Friday 29 August at 14:00, Nikola Mikic defends his PhD dissertation entitled "Skull remodeling surgery in combination with Tumor Treating Fields Therapy as a novel treatment for patients with first recurrence glioblastoma".

Glioblastoma is the deadliest and most common type of primary brain cancer. No significant progress has been made over the last decades regarding treatment. The current PhD project from Aarhus University Hospital examines the efficacy of a new treatment, skull remodeling surgery with electricity for first recurrent glioblastoma in a nationwide randomized clinical trial.

Glioblastoma is a devastating disease that always progresses despite maximum treatment. There are no standardized treatments in the recurrent setting, with an approximate survival of 10 months. Tumor Treating Fields delivers an alternative current by electrodes placed on the scalp, which inhibits cell growth. Skull remodeling surgery aims to enhance Tumor Treating Fields by removing the poorly conductive skull bone through five strategically placed burr holes and overlapping electrode arrays. The PhD project examined the optimal configuration and location of both skull remodeling surgery and electrode array placements using computational head model calculations. Afterwards, the efficacy of the treatment was examined in a nationwide randomized clinical trial.

The summary is written by the PhD student.

The defence is public and takes place in Auditorium G206-124, Entrance G, Aarhus University Hospital and online. Please see the press release for more information. 

Contact

PhD student Nikola Mikic
Mail: nikola@clin.au.dk
 

Read full press release