PhD defence: Rachele Rossi
Extracellular vesicles in peripheral nerve biology
Info about event
Time
Location
Aarhus University, Søauditorierne, Auditorium 1252-310 Jeppe Vontillius
On Thursday 28 May at 13:00, Rachele Rossi defends her PhD dissertation entitled “Extracellular vesicles of peripheral nerves".
How do cells communicate with each other within a biological tissue? One way is through the release of small particles called extracellular vesicles (EVs), which are loaded with molecules that can influence cell behaviors. This PhD project explored the features of EVs derived from peripheral nerves and was conducted by Rachele Rossi.
Peripheral nerves are constituted of different cell types, including neuronal axons and support cells, and their interactions are essential to normal nerve functionality. Although the importance of EVs for peripheral nerve cells has been acknowledged, the study of EVs derived from intact peripheral nerves is an underexplored topic. EVs extracted from whole biological tissue, rather than from cultured cells, provide a more complete snapshot of the biological environment, better capturing the heterogeneity of the cell types and their secretory interactions within the tissue. This Ph.D. project focused on developing a workflow for the isolation and characterization of EVs from murine sciatic nerves, a challenging biological source for EV extraction because of its structural complexity and limited availability. The project investigated the features and cargos of these EVs to frame them in normal peripheral nerve biology; moreover, it was also examined how such EVs may change during aging.
This study provides novel insights on EV biology in peripheral nerves, may bring us closer in understanding how nerve functionality can be affected by aging, and may open potential new avenues for future research in EVs contribution to pathologies affecting peripheral nerves.
The summary is written by the PhD student.
The defence is public and takes place at Aarhus University, Søauditorierne, Auditorium 1252-310 Jeppe Vontillius. Please see the press release for more information.
Contact
PhD student Rachele Rossi
Mail: rachelerossi@biomed.au.dk
Phone: +45 55224694