PhD defence: Stine Sofie Frank Lende
Development of SARS-CoV-2 Neutralizing Antibodies
Info about event
Time
Location
Auditorium G206-142, Aarhus University Hospital
On Friday 1 November at 14:00, Stine Sofie Frank Lende defends her PhD dissertation entitled "SARS-CoV-2 Neutralizing Antibodies - Discovery, Characterization and Delivery".
Coronavirus infections typically give rise to common cold symptoms. However, rare viral variants emerge, causing severe respiratory disease. At the outbreak of the SARS-CoV-2 pandemic in 2020, the lack of specific prophylactic and therapeutic treatment options was limiting for patient care. This PhD thesis explores the development of novel SARS-CoV-2 specific monoclonal antibodies for SARS-CoV-2 prophylaxis, through three stages: 1) Discovery of neutralizing monoclonal antibodies from convalescent individuals. 2) In depth characterization of antibody potency, sensitivity to viral variants, and therapeutic potential of preventing infections in mice. 3) Investigation of the possibility of delivering antibody genetic sequences through Adeno Associated Virus for long-term expression and passive immune-prophylaxis.
The summary is written by the PhD student.
The defence is public and takes place in Auditorium G206-142, Aarhus University Hospital. Please see the press release for more information.
Contact
PhD student Stine Sofie Frank Lende
Mail: sfn@clin.au.dk
Phone: (+45) 60629244