PhD defence: Tine Borum Billeskov
Impact of growth hormone (GH) on skeletal muscle stem cell function and intermediary metabolism: A study in adult patients with newly diagnosed GH-deficiency before and after GH replacement therapy
Info about event
Time
Location
Auditorium Skillerum 1 and 2, second floor, entrance A, Steno Diabetes Center Aarhus, Aarhus University Hospital
On Friday 28 March at 10:00, Tine Borum Billeskov defends her PhD dissertation entitled "Impact of growth hormone (GH) on skeletal muscle stem cell function and intermediary metabolism: A study in adult patients with newly diagnosed GH-deficiency before and after GH replacement therapy".
Skeletal muscle mass (SMM) is essental for locomoton and is a positve predictor of overall health and survival. SMM declines with age and disease. Its preservaton involves various cell types, including muscle stem cells (MuSCs) and fibro-adipogenic progenitors (FAPs), and is influenced by the systemic environment, including insulin, growth hormone (GH), and insulin-like growth factor I. In GH deprived rodent models, GH acutely and transiently increases glucose uptake and suppresses lipolysis, mimicking insulin-like effects, whereas GH-induced lipolysis and insulin resistance prevail in humans. This project aims to assess the impact of GH on MuSC and FAP functon, as well as the acute and long-term effects of GH therapy on substrate metabolism.
The summary is written by the PhD student.
The defence is public and takes place in Auditorium Skillerum 1 and 2 at the second floor, Entrance A, Steno Diabetes Center Aarhus, Aarhus University Hospital. Please see the press release for more information.
Contact
PhD student Tine Borum Billeskov
Mail: tine@clin.au.dk
Phone: 60169141