PhD defence: Yan Hu
A fresh perspective on cellular clean-up: uncovering the hidden role of PI3K complex I in autophagy using yeast
Info about event
Time
Location
Auditorium 1262-101, Aarhus University
On Wednesday 11 June at 13:30, Yan Hu defends her PhD dissertation entitled "The phosphatidylinositol 3-kinase complex I beyond the synthesis of phosphatidylinositol-3-phosphate".
How do cells clean up their own waste to stay healthy? A vital process called autophagy allows cells to degrade and recycle unwanted components, helping maintain cellular health. Impairments in autophagy have been linked to several human diseases such as Alzheimer's disease, Parkinson's disease, cancer, cardivascular disorders, and type 2 diabetes. This PhD thesis focuses on a key player in autophagy, a protein complex called the phosphatidylinositol 3-kinase (PI3K) complex I. This complex plays an essential role in autophagy by producing the phosphatidylinositol-3-phosphate (PtdIns3P), a lipid critical for progression of this pathway. Using backer's yeast as a model organism, the thesis uncovers a previously unknown function of the PI3K complex I, shedding new light on its role in autophagy regulation. These findings advance the current understanding of how autophagy is controlled and may pave the way for developing future therapies targeting autophagy-related diseases.
The summary is written by the PhD student.
The defence is public and takes place in auditorium 1262-101, Aarhus University. Please see the press release for more information.
Contact
PhD student Yan Hu
Mail: yanhu@biomed.au.dk
Phone: +4587159592