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Open calls

PhD project: Premalignant lesions of the cervix

Call for applications for a fully financed PhD project at the Department of Clinical Medicine, Aarhus University, Denmark.

Project aim

Cervical cancer is caused by an infection with human papillomavirus (HPV). While most HPV infections are transient, failure to clear an HPV infection indicates increased risk of persistence and subsequent progression to cervical precancer and cancer. Cervical precancers arising from the squamous epithelium are referred to as cervical intraepithelial neoplasia (CIN) and are typically categorized as grade 1, 2, and 3. A diagnosis of CIN1 does not require surgical treatment, as most lesions reflect benign disease with a high likelihood of regression. In contrast, CIN2 and 3 are typically treated by excision of the transformation zone (i.e. cone biopsy) in most developing countries. However, as studies report high regression rates for CIN2 and because a cone biopsy is associated with increased risk of preterm birth, women of reproductive age with a diagnosis of CIN2 have been managed conservatively (i.e. clinical follow-up and no surgery unless progression to CIN3 or worse) in Central Denmark Region since 1995. However, a CIN2 diagnosis is associated with great interobserver variability and low reproducibility. CIN2 likely represents a mixture of benign HPV disease that will regress without surgical treatment, and evolving CIN3, requiring surgery. Thus, using archived tissue samples from the cervix, we will explore the value of different biomarkers (eg. HPV testing and immunohistochemestry) for the discrimination of the lesions that are likely to regress (i.e. no need of treatment) from those most likely to progress (i.e. surgical treatment recommended). This will enable improved diagnostic and targeted treatment of women at highest risk of progression, which may potentially reduce cervical cancer risk and avoid unnecessary follow-up.

Requested qualifications

Applicants with clinical knowledge on the research subject (for example gynecology or pathology) Applicants with research experience (e.g. epidemiology, laboratory work, HPV)

How to apply

You apply via this link. Application deadline is 8 April 23:59 (midnight) CET

For information about application requirements and mandatory attachments, please see our application guide.

Further information

Preferred date of enrolment start is 1 June 2020.

For more information about the project, please contact Associate professor Anne Hammer Lauridsenahlauridsen@clin.au.dk

Call for applications for enrolment and/or scholarships for the Research Year

The Graduate School of Health is now accepting applications for a number of enrolment and/or scholarships for the Research Year. 

  • Application deadline: 15 April 2020 at midnight
  • Starting date: 1 September 2020*
  • Reply: Medio June 2020

Please pay attention to the criteria for assessment, as well as the guidelines for the Research Year and that you use the correct templates for the mandatory attachments - see the application guide.

Access the application form by clicking on "Research Year Call 2020 04" at the bottom of this page.

*From the application round in April 2020, research year students can no longer postpone their starting date.  Meaning, applicants offered a research year in the April application round must start 1 September 2020